The Harmony One has an canned profile for Flirc, XBMC. For me that is TV on, HDMI 1 Soundbar on, Optical on Video switcher On, Output 3 FireTV Home, Audio Optical. Just add Flirc for Fire TV as a component on your Harmony remote and. My goal was to get my Harmony One to run a FireTV Activity, i.e., turn everything on and switch everything to the correct settings. I know there are IR/RF extenders/converters out there, but I have no idea whether the Harmony 650 will work with them. Out of the box support for Logitech Harmony remote controls with the Harmony FireTV Device. For example, I have several Roku boxes (XDS, etc.) that use IR and therefore work just fine with the Harmony 650, but I recently purchased (and subsequently returned) a Roku stick that uses RF and therefore does not work with the 650. If your devices use RF instead of IR, the 650 won't work with them. The easiest way to tell if your device uses IR is if the remote requires line-of-sight access to the device (can't have the device hidden in a cabinet). Most consumer media devices use IR remotes. The main catch here is that the 650 is an IR (infrared) remote, not an RF (radio frequency) remote. In worst case, if you have the original remotes for your devices, you can 'teach' the 650 to work with the buttons on those remotes. If you have the original Harmony Touch you can also pair it with the hub to give pretty much full Harmony One Ultimate functionality and you get the rather handy simple remote too.

The Smart Hub is a great concept though and the basic model with a simple remote is a very nice package at a good price.

I’m sure most Fire TV Cube reviews will quickly dismiss the port as simply where you connect the included Ethernet adapter, but, if you’re reading this, you probably already know better. FLIRC will allow any IR based remote to control the Fire TV. Logitech appears to regularly update the device database that's used when you configure your Harmony remote. Something that greatly differentiates the Amazon Fire TV Cube from the Fire TV 3 is the Cube’s Micro USB port and the official support for expandability that comes with it.

Dunno for sure, but I'm guessing it will.

Flirc fire tv harmony